Phenobarbital
time:2015-07-29 15:27:35,count:0

Phenobarbital
Alias
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-phenyl-
Barbituric acid, 5-ethyl-5-phenyl-
Category
Non-ionic surfactants-Amide
CAS No.
50-06-6
Molecular Formula & Molecular Weight
Molecular Formula: C12H12N2O3
Molecular Weight: 232.24
Structural Formula
Properties
Appearance: solid.
Solubility: soluble in water; 25℃, 1.11g/L[1].
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: cat oral LDLo: 125mg/Kg;
cat subcutaneous LDLo: 125mg/Kg;
dog oral LD50: 150mg/Kg;
dog subcutaneous LDLo: 150mg/Kg;
frog subcutaneous LDLo: 500mg/Kg;
guinea pig oral LD50: 130mg/Kg;
mouse intramuscular LD50: 175mg/Kg;
mouse intraperitoneal LD50: 88mg/Kg;
mouse intravenous LD50: 218mg/Kg;
mouse oral LD50: 137mg/Kg;
mouse subcutaneous LD50: 228mg/Kg;
rabbit intravenous LD50: 187mg/Kg;
rabbit oral LD50: 185mg/Kg;
rabbit intraperitoneal LDLo: 150mg/Kg;
rabbit subcutaneous LDLo: 150mg/Kg;
rat inhalation LC: > 4.1mg/m3/4H;
rat intraperitoneal LD50: 110mg/Kg;
rat intravenous LD50: 209mg/Kg;
rat oral LD50: 162mg/Kg;
rat rectal LD50: 284mg/Kg;
rat subcutaneous LD50: 200mg/Kg.
reproductive effect
overall carcinogenic evaluation: Group 2B.
Human toxicity[1]: child oral TDLo: 10mg/Kg;
child oral TDLo: 20mg/Kg/I;
human oral TDLo: 18mg/Kg;
infant intramuscular TDLo: 50mg/Kg;
man oral LDLo: 6.485mg/Kg/2W-;
women oral LDLo: 25.272mg/Kg/13;
women oral TDLo: 46mg/Kg.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent hypnotic, sedative abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
Actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 50-06-6

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