Pentobarbital sodium
time:2015-07-29 15:29:00,count:0

Pentobarbital sodium
Alias
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)-, monosodium salt
Barbituric acid, 5-ethyl-5-(1-methylbutyl)-, sodium salt
Category
Anionic surfactants-Amide salt
CAS No.
57-33-0
Molecular Formula & Molecular Weight
Molecular Formula: C11H17NaN2O3
Molecular Weight: 248.25
Structural Formula
Properties
Appearance: solid.
Solubility: soluble in water.
Stability: stable. easily hydrolyzed.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: cat oral LD50: 100mg/Kg;
cat intraperitoneal LDLo: 70mg/Kg;
chicken intraperitoneal LD50: 51.54mg/Kg;
chicken intravenous LD50: 48mg/Kg;
dog oral LD50: 65mg/Kg;
dog intraperitoneal LDLo: 50mg/Kg;
dog intravenous LDLo: 50mg/Kg;
duck oral LD50: 75mg/Kg;
guinea pig intramuscular LD50: 70.3mg/Kg;
guinea pig oral LD50: 60mg/Kg;
guinea pig subcutaneous LD50: 70mg/Kg;
guinea pig intraperitoneal LDLo: 56mg/Kg;
mouse intracerebral LD50: 6.5mg/Kg;
mouse intramuscular LD50: 124mg/Kg;
mouse intraperitoneal LD50: 126mg/Kg;
mouse intravenous LD50: 81mg/Kg;
mouse oral LD50: 239mg/Kg;
mouse subcutaneous LD50: 122mg/Kg;
pigeon oral LD50: 133mg/Kg;
rabbit intraperitoneal LD50: 65mg/Kg;
rabbit intravenous LD50: 40mg/Kg;
rabbit oral LD50: 175mg/Kg;
rabbit parenteral LDLo: 60mg/Kg;
rabbit rectal LDLo: 65mg/Kg;
rat intraduodenal LD50: 39mg/Kg;
rat intraperitoneal LD50: 36mg/Kg;
rat intravenous LD50: 65mg/Kg;
rat oral LD50: 118mg/Kg;
rat subcutaneous LD50: 47mg/Kg;
rat intravenous LDLo: 80mg/Kg.
reproductive effect.
Human toxicity[1]: man oral TDLo: 6.43mg/Kg; women oral TDLo: 60mg/Kg.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent hypnotic, sedative abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
Actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 57-33-0

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