Rifampin
time:2015-08-21 16:47:50,count:0

Rifampin
Alias
Rifamycin, 3-(((4-methyl-1-piperazinyl)imino)methyl)-
Rifampicin
Category
Non-ionic surfactants-Amine
CAS No.
13292-46-1
Molecular Formula & Molecular Weight
Molecular Formula: C43H58N4O12
Molecular Weight: 822.94
Structural Formula
Properties
Appearance: solid.
Solubility: soluble in water, 25℃, 1.4g/L[1].
Stability: stable. Unstable to light.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: guinea pig intraperitoneal LD50: 639mg/Kg;
mouse intraperitoneal LD50: 416mg/Kg;
mouse intravenous LD50: 260mg/Kg;
mouse oral LD50: 500mg/Kg;
mouse subcutaneous LD50: 621mg/Kg;
rabbit oral LD50: 2120mg/Kg;
rat intraperitoneal LD50: 511mg/Kg;
rat oral LD50: 1570mg/Kg;
rat subcutaneous LD50: 534mg/Kg.
reproductive effect.
Human toxicity[1]: human oral TDLo: 180mg/Kg;
man oral LDLo: 857mg/Kg;
man oral TDLo: 13mg/Kg/2D;
man oral TDLo: 814mg/Kg/15W-;
women oral TDLo: 315mg/kg/5W-I;
women oral TDLo: 504mg/kg/42D-;
women oral TDLo: 744mg/kg/9W-I.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent antimicrobial, antibacterial abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 13292-46-1

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