Hydrochlorothiazide
time:2015-09-07 13:34:11,count:0

Hydrochlorothiazide
Alias
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide
Category
Non-ionic surfactants-Amine
CAS No.
58-93-5
Molecular Formula & Molecular Weight
Molecular Formula: C7H8ClN3S2O4
Molecular Weight: 297.74
Structural Formula
Properties
Appearance: solid.
Solubility: slightly soluble in water, 25℃, 0.722g/L[1].
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: dog intravenous LD50: 250mg/Kg;
mouse intraperitoneal LD50: 578mg/Kg;
mouse intravenous LD50: 590mg/Kg;
mouse oral LD50: 1175mg/Kg;
mouse subcutaneous LD50: 1470mg/Kg;
rabbit intravenous LD50: 461mg/Kg;
rat intraperitoneal LD50: 234mg/Kg;
rat intravenous LD50: 990mg/Kg;
rat oral LD50: 2750mg/Kg;
rat subcutaneous LD50: 1270mg/Kg.
Human toxicity[1]: man oral TDLo: 12.857mg/Kg/9D;
man oral TDLo: 75mg/Kg/30W-I;
women oral LDLo: 2.5mg/Kg/5D-;
women oral TDLo: 0.25mg/Kg;
women oral TDLo: 0.5mg/Kg;
women oral TDLo: 2mg/Kg/12H-I;
women oral TDLo: 34.884mg/Kg/30.
overall carcinogenic evaluation: Group 3.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent diuretic, antihypertensive, dispersing, emulsifying abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 58-93-5

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