Dextran sulfate
Time: 2012-09-27 17:30:25
Dextran sulfate
Synonyms
Dextran, hydrogen sulfate;
Sulfuric acid, dextran ester;
Dextran sulfuric acid ester;
Category
Anionic Surfactant
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>> Sugar Sulfate
>> Polysaccharide Group Sulfate
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Chemical Numbering System
CASRN9042-14-2
EINECSN/A
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Schematic formula:
Properties
Appearance    (1), powder.
Solubility    soluble in water.
Stability    stable in alkali, weak acid and hard water; unstable in strong acid, hydrolyzed.
Risk    Solid form: irritation, irritation to skin, eye.
GHS (Rev.6) label:  
Animal Toxicity
Table 1 Animal toxicity values
mouse intraperitoneal LD50
341mg/kg[1]
Ecology    may be hazardous to environment. Water body should be given special attention.
Biodegradability    biodegradable.
Characteristics    excellent emulsifying, dispersing, film-forming abilities.
Synthesis
Dextran and sulfur trioxide react, finally obtain product.
US patent 4,855,416 (Method for the manufacture of dextran sulfate and salts thereof) presents a synthetic process.
Quality Standards & Test Methods
1. Physical and chemical indexes
Item
Physical and chemical indexes
Actives, %, ≥
85.0
Loss on drying, %, ≤
10.0
Test Methods
(1), Actives
 
(2), Loss on drying
105°C, 6h.
2. Hazardous substances indexes
Item
Hazardous substances indexes
Heavy metals (as Pb), mg/Kg, ≤
20
As, mg/Kg, ≤
3
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents - Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents - Determination of total arsenic
3. Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances; or furtherly test for microorganisms.
(c), Used in medicine, must comply with pharmacopoeia execution.
Major Uses
1. Typical applications
Use as dispersing agent, emulsifying agent.
2. Personal care products
Conditioning agent, water retaining agent in personal care products.
3. Medicine
Use as pharmaceutical ingredient. (The contents of this section are for reference only and should be subject to pharmacopoeia.)
Manufacturers
 
References
[1]: ChemIDplus. 9042-14-2, Dextran sulfate
Update: 20131022(1); 20170225(2);