Sodium dextran sulfate
Time: 2012-09-27 17:31:08
Sodium dextran sulfate
Synonyms
Dextran sulfate sodium;
Dextran, hydrogen sulfate, sodium salt;
Category
Anionic Surfactant
>> Sulfate
>> Sugar Sulfate
>> Polysaccharide Group Sulfate
>> Polysaccharide Sulfate
Chemical Numbering System
CASRN9011-18-1
EINECSN/A
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Schematic formula:
Properties
Appearance    (1), powder.
Solubility    soluble in water.
Stability    stable in alkali, weak acid and hard water; unstable in strong acid, hydrolyzed.
Risk    Solid form: irritation, irritation to skin, eye.
GHS (Rev.6) label:  
Animal Toxicity
Table 1 Animal toxicity values
rat oral LD50
20600mg/kg[1]
rat intravenous LD50
473mg/kg[1]
mouse oral LD50
25200mg/kg[1]
mouse intravenous LD50
2350mg/kg[1]
rabbit intravenous LD50
19000mg/kg[1]
Ecology    may be hazardous to environment. Water body should be given special attention.
Biodegradability    biodegradable.
Characteristics    excellent emulsifying, dispersing, film-forming, thickening abilities.
Synthesis
Dextran and sulfur trioxide react, then sodium hydroxide neutralizes, finally obtain product.
US patent 4,855,416 (Method for the manufacture of dextran sulfate and salts thereof) presents a synthetic process.
Quality Standards & Test Methods
1. Physical and chemical indexes
Item
Physical and chemical indexes
Actives, %, ≥
85.0
Loss on drying, %, ≤
10.0
Test Methods
(1), Actives
 
(2), Loss on drying
105°C, 6h.
2. Hazardous substances indexes
Item
Hazardous substances indexes
Heavy metals (as Pb), mg/Kg, ≤
20
As, mg/Kg, ≤
3
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents - Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents - Determination of total arsenic
3. Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances; or furtherly test for microorganisms.
(c), Used in medicine, must comply with pharmacopoeia execution.
Major Uses
1. Typical applications
Use as dispersing agent, emulsifying agent.
Use as thickening agent.
2. Personal care products
Gel-forming agent, viscosity controlling agent in personal care products.
3. Medicine
Use as pharmaceutical ingredient. (The contents of this section are for reference only and should be subject to pharmacopoeia.)
Manufacturers
 
References
[1]: ChemIDplus. 9011-18-1, Sodium dextran sulfate
Update: 20131022(1); 20170225(2);