Melittin
Time: 2020-07-24 18:39:50

Melittin

Synonyms

L-Glutamamide, glycyl-L-isoleucyl-glycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonyl-glycyl-L-leucyl-L-prolyl-L-alanyl-L-leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-;

Category

Non-ionic surfactant

> Amine

>> Peptide and its Derivatives

Chemical Numbering System

CASRN: 20449-79-0

EINECS: N/A

Molecular Formula & Molecular Weight

Molecular Formula: C131H229N39O31

Molecular Weight: 2846.46

Structure

Properties

Appearance    (1), solid.

Solubility    soluble in water.

Stability    stable.

Risk    Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.

GHS (Rev.8) label:  

Animal Toxicity

Table 1 Animal toxicity values

guinea pig intraperitoneal LD50

2.75mg/kg[1]

mouse intraperitoneal LD50

7.4mg/kg[1]

mouse intravenous LD50

7.04mg/kg[1]

rat intraperitoneal LD50

17.7mg/kg[1]

rat intravenous LDLo

1.4mg/kg[1]

Ecology    may be hazardous to environment. Water body should be given special attention.

Biodegradability    biodegradable.

Characteristics    excellent antibacterial, anti-inflammatory, antiviral abilities.

Note    (1), Strong hemolytic characteristic.

Synthesis

 

Quality Standards & Test Methods

1, Physical and chemical indexes

Item

Physical and chemical indexes

Solid

Actives, %, ≥

95.0

Test Methods

(1), Actives

GB/T 13173 Surface active agents -- Detergents -- Testing methods

2, Hazardous substances indexes

Item

Hazardous substances indexes

Solid

Heavy metals (as Pb), mg/Kg, ≤

20

As, mg/Kg, ≤

3

Test Methods

(1), Heavy metals (as Pb)

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30799 The test method of food detergents -- Determination of heavy metals

(2), As

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30797 The test method of food detergents -- Determination of total arsenic

3, Further explanation

(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.

(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.

Major Uses

1, Typical applications

Use as anti-inflammatory agent.

2, Personal care products

Anti-seborrheic agent in personal care products.

Manufacturers

 

References

[1]: ChemIDplus. 20449-79-0, Melittin