Basic blue 9
Time: 2022-05-07 12:41:52; Reading: 0

Basic blue 9

Synonyms

CI 52015;

Methylene blue;

Methylthioninium chloride;

Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride (1:1);

Category

Cationic surfactant

> Thiazinonium Salt

Chemical Numbering System

CASRN: 61-73-4

EINECS: 200-515-2

Molecular Formula & Molecular Weight

Molecular Formula: C16H18ClN3S; C16H18N3S.Cl

Molecular Weight: 319.85

Structure

Properties

Appearance    (1), solid.

Solubility    soluble in water.

Physical - chemical properties

Water solubility, g/L

43.6 (25 °C)[1]

Stability    stable.

Risk    Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.

GHS (Rev.9) label:  

Animal Toxicity

Table 1 Animal toxicity values

cat intravenous LDLo

41mg/kg[2]

dog intravenous LDLo

50mg/kg[2]

dog oral LDLo

500mg/kg[2]

guinea pig subcutaneous LDLo

300mg/kg[2]

monkey intravenous LDLo

10mg/kg[2]

mouse intraperitoneal LD50

150mg/kg[2]

mouse intravenous LD50

77mg/kg[2]

mouse oral LD50

3500mg/kg[2]

rabbit oral LDLo

1000mg/kg[2]

rat intraperitoneal LD50

180mg/kg[2]

rat intravenous LD50

1250mg/kg[2]

rat oral LD50

1180mg/kg[2]

rat subcutaneous LD50

190mg/kg[2]

Human Toxicity

Table 2 Human toxicity values

man subcutaneous TDLo

0.028mL/kg[2]

Ecology    may be hazardous to environment. Water body should be given special attention.

Biodegradability    biodegradable.

Characteristics    excellent dyeing, masking, dispersing, antistatic abilities. Thiazine dyes.

Synthesis

 

Quality Standards & Test Methods

1, Physical and chemical indexes

Item

Physical and chemical indexes

Solid

Actives, %, ≥

90.0

Test Methods

(1), Actives

GB/T 13173 Surface active agents -- Detergents -- Testing methods

2, Hazardous substances indexes

Item

Hazardous substances indexes

Solid

Heavy metals (as Pb), mg/kg, ≤

20

As, mg/kg, ≤

3

Test Methods

(1), Heavy metals (as Pb)

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30799 The test method of food detergents -- Determination of heavy metals

(2), As

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30797 The test method of food detergents -- Determination of total arsenic

3, Product standards

(1), Chinese standards

(1a), Chinese Pharmacopoeia (2020 Edition) Methylthioninium Chloride

4, Further explanation

(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.

Major Uses

1, Typical applications

Use as dye.

2, Medicine

Use as pharmaceutical ingredient (antidote). (This section is for reference only, should be implemented according to local Pharmacopoeia.)

3, Reagent

Use as indicator.

Manufacturers

 

References

[1]: HSDB. Methylene blue, 61-73-4

[2]: ChemIDplus. Methylene blue, 61-73-4