Megestrol acetate
Synonyms
17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate;
17alpha-Acetoxy-6-methylpregna-4,6-diene-3,20-dione;
Category
Non-ionic surfactant
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Chemical Numbering System
CAS: 595-33-5
EINECS: 209-864-5
Molecular Formula & Molecular Weight
Molecular Formula: C24H32O4
Molecular Weight: 384.51
Structure
Properties
Appearance (1), solid.
Solubility insoluble in water.
Stability stable. Under strong acid or strong alkali condition, easily hydrolyzed.
Risk Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS label: 
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent lubricating, dispersing, emulsifying, anti-inflammatory abilities. Hormone. Not to be used in personal care products.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
|
Item |
Physical and chemical indexes |
|
Solid |
|
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents -- Detergents -- Testing methods
2, Hazardous substances indexes
|
Item |
Hazardous substances indexes |
|
Solid |
|
|
Heavy metals (as Pb), mg/kg, ≤ |
20 |
|
As, mg/kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents -- Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents -- Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2020 Edition) Megestrol Acetate
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
Major Uses
1, Typical applications
Use as lubricant.
Use as dispersing agent, emulsion stabilizer.
Use as anti-inflammatory agent.
2, Medicine
Use as pharmaceutical ingredient (progestational hormones). (This section is for reference only, should be implemented according to local Pharmacopoeia.)
Manufacturers