Itraconazole
time:2012-11-08 03:30:33,count:0

Itraconazole
Alias
3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-
Category
Non-ionic surfactants-Amine
CAS No.
84625-61-6
Molecular Formula & Molecular Weight
Molecular Formula: C35H38Cl2N8O4
Molecular Weight: 705.63
Structural Formula
Properties
Appearance: solid.
Solubility: insoluble in water.
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: rat oral LD50: >320mg/Kg;
rat intravenous LD50: 40mg/Kg;
mouse oral LD50: >320mg/Kg;
mouse intravenous LD50: 46.4mg/Kg;
guinea pig oral LD50: >160mg/Kg;
dog oral LD50: >200mg/Kg.
reproductive effect.
Human toxicity[1]: man oral TDLo: 240mg/Kg/6W-I;
women oral TDLo: 32mg/Kg/8D-I;
women oral TDLo: 140mg/Kg/5W-I.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent antimicrobial, antibacterial, anti-infective abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
Actives*, %, ≥
99
 
*: should be marked on molecular weight.
Major Uses
Use as antimicrobial agent.
Bactericide in personal care products.
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/:84625-61-6
Update: 20130918(1);

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