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Chlorobutanol

Time:2012-12-06 15:35:21; Reading: 11

Chlorobutanol

Synonyms

2-Propanol, 1,1,1-trichloro-2-methyl-;

Category

Non-ionic surfactant

> Alcohol

>> Derivative of Fatty Alcohol

Chemical Numbering System

CASRN: 57-15-8

EINECS: 200-317-6

Molecular Formula & Molecular Weight

Molecular Formula: C4H7Cl3O

Molecular Weight: 177.46

Structure

Properties

Appearance    (1), colorless to white crystal.

Solubility    soluble in water.

Physical - chemical properties

Water solubility, g/L

8 (20°C)[1]

Stability    stable.

Risk    Solid form: irritation, irritation to skin, eye, respiratory system.

GHS (Rev.10) label: 

Animal Toxicity

Table 1 Animal toxicity values

dog oral LDLo

238mg/kg[2]

frog parenteral LDLo

800mg/kg[2]

rabbit oral LDLo

213mg/kg[2]

Reproductive effect[2].

Ecology    may be hazardous to environment. Water body should be given special attention.

Biodegradability    biodegradable.

Characteristics    excellent antimicrobial, antibacterial, preservative abilities.

Synthesis

 

Quality Standards & Test Methods

1, Physical and chemical indexes

Item

Physical and chemical indexes

Solid

Actives, %, ≥

95.0

Test Methods

(1), Actives

GB/T 13173 Surface active agents - Detergents - Testing methods

2, Hazardous substances indexes

Item

Hazardous substances indexes

Solid

Heavy metals (as Pb), mg/Kg, ≤

20

As, mg/Kg, ≤

3

Test Methods

(1), Heavy metals (as Pb)

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30799 The test method of food detergents - Determination of heavy metals

(2), As

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30797 The test method of food detergents - Determination of total arsenic

3, Product standards

(1), Chinese standards

(1a), Chinese Pharmacopoeia (2015 Edition) Chlorobutanol

4, Further explanation

(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.

(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.

Major Uses

1, Typical applications

Use as antimicrobial agent, antibacterial agent, preservative.

2, Personal care products

Antimicrobial agent in personal care products.

Further information:

(1), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the allowed preservatives. Maximum concentration is 0.5%.

Not to be used in aerosol dispensers (sprays).

Must mark on the label: Contains Chlorobutanol.

(2), In accordance with EU regulations (EC) No 1223/2009, directive 86/199/EEC, be included in Annex V/11. Maximum concentration is 0.5%.

Not to be used in aerosol dispensers (sprays).

Must mark on the label: Contains Chlorobutanol.

3, Medicine

Pharmaceutical excipient, use as bacteriostat, plasticizer. (This section is for reference only, should be implemented according to local Pharmacopoeia.)

4, Polymer

Plasticizer in cellulose esters and ethers.

Manufacturers

 

References

[1]: HSDB. 57-15-8, Chloretone

[2]: ChemIDplus. 57-15-8, Chlorobutanol

Update: 20130920(1); 20190922(2)

Document

[Terminology] Dispersion system

[Terminology] Vesicle

Pandect of Ester surfactants (1): Definition

[Terminology] Van Der Waals force

[Terminology] Micellar aggregation number

Standard

Test methods of surfactants, catalog, Chinese national standards

Surfactants, catalog, Chinese national standards

Test methods of materials, catalog, Chinese national standards

Basic standards of materials, catalog, Chinese national standards

Test methods of textile auxiliaries, catalog, Chinese national standards