Chlorobutanol
Synonyms
2-Propanol, 1,1,1-trichloro-2-methyl-;
Category
Non-ionic surfactant
> Alcohol
>> Derivative of Fatty Alcohol
Chemical Numbering System
CASRN: 57-15-8
EINECS: 200-317-6
Molecular Formula & Molecular Weight
Molecular Formula: C4H7Cl3O
Molecular Weight: 177.46
Structure
Properties
Appearance (1), colorless to white crystal.
Solubility soluble in water.
Physical - chemical properties
Water solubility, g/L |
8 (20°C)[1] |
Stability stable.
Risk Solid form: irritation, irritation to skin, eye, respiratory system.
GHS (Rev.10) label:
Animal Toxicity
Table 1 Animal toxicity values
dog oral LDLo |
238mg/kg[2] |
frog parenteral LDLo |
800mg/kg[2] |
rabbit oral LDLo |
213mg/kg[2] |
Reproductive effect[2].
Ecology may be hazardous to environment. Water body should be given special attention.
Biodegradability biodegradable.
Characteristics excellent antimicrobial, antibacterial, preservative abilities.
Synthesis
Quality Standards & Test Methods
1, Physical and chemical indexes
Item |
Physical and chemical indexes |
Solid |
|
Actives, %, ≥ |
95.0 |
Test Methods
(1), Actives
GB/T 13173 Surface active agents - Detergents - Testing methods
2, Hazardous substances indexes
Item |
Hazardous substances indexes |
Solid |
|
Heavy metals (as Pb), mg/Kg, ≤ |
20 |
As, mg/Kg, ≤ |
3 |
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents - Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents - Determination of total arsenic
3, Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Chlorobutanol
4, Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances or furtherly test for microorganisms, according to local regulations and standards.
Major Uses
1, Typical applications
Use as antimicrobial agent, antibacterial agent, preservative.
2, Personal care products
Antimicrobial agent in personal care products.
Further information:
(1), In accordance with Safety and Technical Standards for Cosmetics (2015 Edition) of China, be included in the allowed preservatives. Maximum concentration is 0.5%.
Not to be used in aerosol dispensers (sprays).
Must mark on the label: Contains Chlorobutanol.
(2), In accordance with EU regulations (EC) No 1223/2009, directive 86/199/EEC, be included in Annex V/11. Maximum concentration is 0.5%.
Not to be used in aerosol dispensers (sprays).
Must mark on the label: Contains Chlorobutanol.
3, Medicine
Pharmaceutical excipient, use as bacteriostat, plasticizer. (This section is for reference only, should be implemented according to local Pharmacopoeia.)
4, Polymer
Plasticizer in cellulose esters and ethers.
Manufacturers
References
[1]: HSDB. 57-15-8, Chloretone
[2]: ChemIDplus. 57-15-8, Chlorobutanol
Update: 20130920(1); 20190922(2)