Sodium guaiazulene sulfonate
Time: 2013-05-31 02:06:13
Sodium guaiazulene sulfonate
Synonyms
Sodium 5-isopropyl-3,8-dimethyl-1-azulene sulfonate;
Sodium gualenate;
Category
Anionic Surfactant
>> Sulfonate
>> Aryl Sulfonate
>> Bridge-ring Group Sulfonate
>> Branched Alkyl Bridge-ring Group Sulfonate
Chemical Numbering System
CASRN6223-35-4
EINECS228-309-8
Molecular Formula & Molecular Weight
Molecular Formula: C15H17NaO3S; C15H18O3S.Na
Molecular Weight: 300.35
Structure
Properties
Appearance    (1), solid.
Solubility    soluble in water.
Stability    stable.
Risk    Solid form: flammable material; irritation, irritation to skin, eye, respiratory. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.
GHS (Rev.6) label:  
Animal Toxicity
Table 1 Animal toxicity values
mouse intraperitoneal LD50
105mg/kg[1]
mouse oral LD50
1540mg/kg[1]
rat intraperitoneal LD50
180mg/kg[1]
rat oral LD50
6380mg/kg[1]
rat subcutaneous LD50
520mg/kg[1]
Ecology    may be hazardous to environment. Water body should be given special attention.
Biodegradability    biodegradable.
Characteristics    excellent anti-inflammatory, anti-allergy, dispersing, emulsifying abilities.
Note    (1), A sesquiterpenoid compound (azulene compound).
Synthesis
Guaiazulene and sulfur trioxide react, then obtain product.
Refer to:
China patent CN1803768A Process for the synthesis of 2-hydroxy-4-alkyloxy benzophenone, etc.
Quality Standards & Test Methods
1. Physical and chemical indexes
Item
Physical and chemical indexes
Solid
Actives, %, ≥
90.0
Test Methods
(1), Actives
GB/T 5173 Surface active agents and detergents-Determination of anionic-active matter by direct two-phase titration procedure
ISO 2271 Surface active agents -- Detergents -- Determination of anionic-active matter by manual or mechanical direct two-phase titration procedure
2. Hazardous substances indexes
Item
Hazardous substances indexes
Solid
Heavy metals (as Pb), mg/Kg, ≤
20
As, mg/Kg, ≤
3
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents - Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents - Determination of total arsenic
3. Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances; or furtherly test for microorganisms.
Major Uses
1. Typical applications
Use as anti-inflammatory ingredient.
2. Personal care products
Use as conditioning agent.
3. Medicine
Use as pharmaceutical ingredient (for example: anti-inflammatory ingredient). (Used in medicine, must comply with local pharmacopoeia execution.)
Manufacturers
 
References
[1]: ChemIDplus. 6223-35-4, Sodium gualenate
Update: 20131025(1); 20170425(2);