Sodium chondroitin sulfate
Time: 2013-06-02 05:12:51
Sodium chondroitin sulfate
Synonyms
Chondroitin, hydrogen sulfate, sodium salt;
Chondroitin Sulfate Sodium;
Category
Anionic Surfactant
>> Sulfate
>> Sugar Sulfate
>> Polysaccharide Group Sulfate
>> Polysaccharide Sulfate
Chemical Numbering System
CASRN9082-07-9
EINECSN/A
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Structure
Schematic formula:
Properties
Appearance    (1), white to slightly yellow powder.
Solubility    soluble in water.
Stability    stable in alkali, weak acid and hard water; unstable in strong acid, hydrolyzed.
Risk    Solid form: irritation, irritation to skin, eye.
GHS (Rev.6) label:  
Animal Toxicity
Table 1 Animal toxicity values
mouse intraperitoneal LD50
9800mg/kg[1]
mouse intravenous LD50
4980mg/kg[1]
mouse oral LD50
> 10000mg/kg[1]
mouse subcutaneous LD50
> 10000mg/kg[1]
rat intraperitoneal LD50
2900mg/kg[1]
rat intravenous LD50
> 3125mg/kg[1]
rat oral LD50
> 10000mg/kg[1]
rat subcutaneous LD50
3700mg/kg[1]
Reproduction: reproductive effect[1].
Ecology    may be hazardous to environment. Water body should be given special attention.
Biodegradability    biodegradable.
Characteristics    excellent emulsifying, dispersing, film-forming, thickening abilities. Acidic mucopolysaccharide.
Synthesis
US patent 6,342,367 (Method for the preparation of chondroitin sulfate compounds) presents a preparation process.
US patent 9,149,572 (Chondroitin sulfate having decreased molecular weight and use thereof) describes a low molecular weight chondroitin sulfate.
Quality Standards & Test Methods
1. Physical and chemical indexes
Item
Physical and chemical indexes
Actives, %, ≥
85.0
Loss on drying, %, ≤
10.0
Test Methods
(1), Actives
 
(2), Loss on drying
105°C, 4h.
2. Hazardous substances indexes
Item
Hazardous substances indexes
Heavy metals (as Pb), mg/Kg, ≤
20
As, mg/Kg, ≤
3
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents - Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents - Determination of total arsenic
3. Product standards
(1), Chinese standards
(1a), Chinese Pharmacopoeia (2015 Edition) Chondroitin sulfate sodium
4. Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances; or furtherly test for microorganisms.
(c), Used in medicine, must comply with pharmacopoeia execution.
Major Uses
1. Typical applications
Use as dispersing agent, emulsifying agent.
Use as thickening agent.
2. Personal care products
Conditioning agent, antistatic agent in personal care products.
3. Medicine
Use as pharmaceutical ingredient. (The contents of this section are for reference only and should be subject to pharmacopoeia.)
Manufacturers
 
References
[1]: ChemIDplus. 9082-07-9, Chondroitin, hydrogen sulfate, sodium salt
Update: 20131022(1); 20170225(2);