Chondroitin 4-sulfate
Time: 2013-06-02 05:14:10
Chondroitin 4-sulfate
Chondroitin sulfate A;
Chondroitin, 4-(hydrogen sulfate);
Anionic Surfactant
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Chemical Numbering System
Molecular Formula & Molecular Weight
Molecular Formula: N/A
Molecular Weight: N/A
Schematic formula:
Appearance    (1), white to slightly yellow powder.
Solubility    soluble in water.
Stability    stable in alkali, weak acid and hard water; unstable in strong acid, hydrolyzed.
Risk    Solid form: irritation, irritation to skin, eye.
GHS (Rev.6) label:  
Animal Toxicity
Table 1 Animal toxicity values
mouse intravenous LD50
mouse oral LD
> 15000mg/kg[1]
Ecology    may be hazardous to environment. Water body should be given special attention.
Biodegradability    biodegradable.
Characteristics    excellent emulsifying, dispersing, film-forming, thickening abilities. Acidic mucopolysaccharide.
US patent 6,342,367 (Method for the preparation of chondroitin sulfate compounds) presents a preparation process.
US patent 9,149,572 (Chondroitin sulfate having decreased molecular weight and use thereof) describes a low molecular weight chondroitin sulfate.
Quality Standards & Test Methods
1. Physical and chemical indexes
Physical and chemical indexes
Actives, %, ≥
Loss on drying, %, ≤
Test Methods
(1), Actives
(2), Loss on drying
105°C, 4h.
2. Hazardous substances indexes
Hazardous substances indexes
Heavy metals (as Pb), mg/Kg, ≤
As, mg/Kg, ≤
Test Methods
(1), Heavy metals (as Pb)
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30799 The test method of food detergents - Determination of heavy metals
(2), As
Safety and Technical Standards for Cosmetics (2015 Edition)
GB/T 30797 The test method of food detergents - Determination of total arsenic
3. Further explanation
(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.
(b), Used in cosmetics, should be test for harmful substances; or furtherly test for microorganisms.
(c), Used in medicine, must comply with pharmacopoeia execution.
Major Uses
1. Typical applications
Use as dispersing agent, emulsifying agent.
Use as thickening agent.
2. Personal care products
Reference to chondroitin sulfates.
3. Medicine
Use as pharmaceutical ingredient. (The contents of this section are for reference only and should be subject to pharmacopoeia.)
[1]: ChemIDplus. 24967-93-9, Chondroitin sulfate A
Update: 20131022(1); 20170225(2);