Diphenhydramine HCl
time:2013-08-10 01:04:44,count:0

Diphenhydramine HCl
Alias
Diphenhydramine hydrochloride
Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, hydrochloride (1:1)
Category
Non-ionic surfactants-Amine
CAS No.
147-24-0
Molecular Formula & Molecular Weight
Molecular Formula: C17H22ClNO
Molecular Weight: 291.82
Structural Formula
Properties
Appearance: solid.
Solubility: soluble in water.
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: dog intravenous LD50: 24mg/Kg;
guinea pig intraperitoneal LD50: 75mg/Kg;
guinea pig oral LD50: 280mg/Kg;
guinea pig subcutaneous LD50: 40mg/Kg;
hamster intravenous LD50: 18mg/Kg;
mouse intraperitoneal LD50: 56mg/Kg;
mouse intravenous LD50: 20mg/Kg;
mouse oral LD50: 164mg/Kg;
mouse subcutaneous LD50: 99.2mg/Kg;
pigeon intramuscular LD50: 63mg/Kg;
rabbit intravenous LD50: 10mg/Kg;
rat intraperitoneal LD50: 82mg/Kg;
rat intravenous LD50: 35mg/Kg;
rat oral LD50: 500mg/Kg;
rat subcutaneous LD50: 201mg/Kg.
reproductive effect.
Human toxicity[1]: child oral TDLo: 12.5mg/Kg;
child oral TDLo: 60mg/kg/6H-I;
man oral TDLo: 10.714mg/Kg;
women oral TDLo: 83mg/Kg.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent antistatic, dispersing, emulsifying, anticorrosive abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
Actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Use as antistatic agent.
Use as dispersing agent, emulsifying agent.
Conditioning agent in personal care products.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 147-24-0

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