Adriamycin
time:2015-04-30 18:15:42,count:0

Adriamycin
Alias
Doxorubicin
5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S,10S)-
Category
Non-ionic surfactants-Sugar
CAS No.
23214-92-8
Molecular Formula & Molecular Weight
Molecular Formula: C27H29NO11
Molecular Weight: 543.52
Structural Formula
Properties
Appearance: solid.
Solubility: slightly soluble in water.
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: dog intravenous LD50: 2.4mg/Kg;
mouse intraperitoneal LD50: 10.7mg/Kg;
mouse intravenous LD50: 10mg/Kg;
mouse oral LD50: 570mg/Kg;
mouse intratracheal LDLo: 2.4mg/Kg;
rabbit intravenous LD50: 5mg/Kg;
rabbit intrapleural LDLo: 0.4mg/Kg;
rat intraperitoneal LD50: 16mg/Kg;
rat intravenous LD50: 10.51mg/Kg.
reproductive effect.
Human toxicity[1]: human intravenous LDLo: 0.4mg/Kg;
human intravenous TDLo: 15mg/Kg/D;
human intravenous TDLo: 380mg/Kg/31W.
overall carcinogenic evaluation: Group 2A.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent antineoplastic, dispersing abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
Actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 23214-92-8

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