Adriamycin hydrochloride
time:2015-04-30 18:16:12,count:0

Adriamycin hydrochloride
Alias
Doxorubicin hydrochloride
Doxorubicin HCl
5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
Category
Non-ionic surfactants-Sugar
CAS No.
25316-40-9
Molecular Formula & Molecular Weight
Molecular Formula: C27H30ClNO11
Molecular Weight: 579.98
Structural Formula
Properties
Appearance: solid.
Solubility: soluble in water.
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: mouse intramuscular LD50: 13.7mg/Kg;
mouse intraperitoneal LD50: 11.16mg/Kg;
mouse intravenous LD50: 1.245mg/Kg;
mouse oral LD50: 698mg/Kg;
mouse subcutaneous LD50: 7.678mg/Kg;
rabbit intravenous LD50: 5.98mg/Kg;
rat intramuscular LD50: 16mg/Kg;
rat intraperitoneal LD50: 16.03mg/Kg;
rat intravenous LD50: 12.51mg/Kg;
rat subcutaneous LD50: 21.84mg/Kg.
reproductive effect.
Human toxicity[1]: man intravenous LDLo: 2.571mg/Kg/3W-;
man intravenous TDLo: 12mg/kg/26W-I.
overall carcinogenic evaluation: Group 2A.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent antineoplastic, dispersing abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
Actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 25316-40-9

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