Daunorubicin
time:2015-04-30 18:17:40,count:0

Daunorubicin
Alias
5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-
Daunomycin
Category
Non-ionic surfactants-Sugar
CAS No.
20830-81-3
Molecular Formula & Molecular Weight
Molecular Formula: C27H29NO10
Molecular Weight: 527.52
Structural Formula
Properties
Appearance: solid.
Solubility: slightly soluble in water.
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: dog intravenous LD50: 4mg/Kg;
guinea pig intravenous LD50: 6mg/Kg;
hamster intravenous LDLo: 50mg/Kg;
mouse intraperitoneal LD50: 2.5mg/Kg;
mouse intravenous LD50: 8.6mg/Kg;
mouse oral LD50: 205mg/Kg;
rabbit intravenous LD50: 5mg/Kg;
rat intraperitoneal LD50: 20mg/Kg;
rat intravenous LD50: 13mg/Kg;
rat oral LD50: 336mg/Kg;
rat subcutaneous LD50: 33.2mg/Kg.
reproductive effect.
Human toxicity[1]: child oral LDLo: 10mg/Kg/30D-I;
Human oral LDLo: 6mg/Kg.
overall carcinogenic evaluation: Group 2B.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent antineoplastic, dispersing abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
Actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 20830-81-3

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