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Doxycycline

Time:2015-05-02 16:54:32; Reading: 6

Doxycycline

Synonyms

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)-;

Category

Non-ionic surfactant

> Amine

>> Alicyclic Amine

>>> Polycyclic Amine

Chemical Numbering System

CASRN: 564-25-0

EINECS: 209-271-1

Molecular Formula & Molecular Weight

Molecular Formula: C22H24N2O8

Molecular Weight: 444.43

Structure

Properties

Appearance    (1), solid.

Solubility    slightly soluble in water.

Stability    stable.

Risk    Solid form: flammable material; irritation, irritation to skin, eye, respiratory system. Harmful products of combustion are CO, CO2 and so on. Contact with strong oxidants, can cause to burn.

GHS (Rev.10) label:  

Animal Toxicity

Table 1 Animal toxicity values

dog intravenous LD50

> 100mg/kg[1]

dog oral LD50

> 500mg/kg[1]

mouse intraperitoneal LD50

410mg/kg[1]

mouse intravenous LD50

241mg/kg[1]

mouse oral LD50

1870mg/kg[1]

rat intraperitoneal LD50

378mg/kg[1]

rat intravenous LD50

228mg/kg[1]

rat oral LD50

> 2000mg/kg[1]

Reproductive effect[1].

Human Toxicity

Table 2 Human toxicity values

women oral TDLo

68mg/kg/24D-I[1]

Ecology    may be hazardous to environment. Water body should be given special attention.

Biodegradability    biodegradable.

Characteristics    excellent antimicrobial, antibacterial, anti-infective abilities.

Synthesis

 

Quality Standards & Test Methods

1, Physical and chemical indexes

Item

Physical and chemical indexes

Solid

Actives, %, ≥

95.0

Test Methods

(1), Actives

GB/T 13173 Surface active agents -- Detergents -- Testing methods

2, Hazardous substances indexes

Item

Hazardous substances indexes

Solid

Heavy metals (as Pb), mg/Kg, ≤

20

As, mg/Kg, ≤

3

Test Methods

(1), Heavy metals (as Pb)

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30799 The test method of food detergents -- Determination of heavy metals

(2), As

Safety and Technical Standards for Cosmetics (2015 Edition)

GB/T 30797 The test method of food detergents -- Determination of total arsenic

3, Further explanation

(a), On physical and chemical indexes: firstly, shall be indicated carbon atom distribution; secondly, shall be indicated average molecular weight.

Major Uses

1, Typical applications

Use as antibiotic.

Manufacturers

 

References

[1]: ChemIDplus. 564-25-0, Doxycycline

Update: 20200718(1);

Document

[Terminology] Dispersion system

[Terminology] Vesicle

Pandect of Ester surfactants (1): Definition

[Terminology] Van Der Waals force

[Terminology] Micellar aggregation number

Standard

Test methods of surfactants, catalog, Chinese national standards

Surfactants, catalog, Chinese national standards

Test methods of materials, catalog, Chinese national standards

Basic standards of materials, catalog, Chinese national standards

Test methods of textile auxiliaries, catalog, Chinese national standards