Bleomycin
time:2015-06-07 20:06:36,count:0

Bleomycin
Alias
Bleomycine
Category
Cationic surfactants-Sulfonium salt
CAS No.
11056-06-7
Structural Formula
Basic ingredient:
Properties
Appearance: solid.
Solubility: soluble in water.
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: dog oral LD: > 100mg/Kg;
mouse intramuscular LD50: 270mg/Kg;
mouse intraperitoneal LD50: 35mg/Kg;
mouse intravenous LD50: 53mg/Kg;
mouse oral LD50: > 2000mg/Kg;
mouse subcutaneous LD50: 188mg/Kg;
mouse intratracheal LDLo: 14mg/Kg;
rat oral LD: > 200mg/Kg;
rat intraperitoneal LD50: 168mg/Kg;
rat subcutaneous LD50: 168mg/Kg;
rat intratracheal LDLo: 4units/Kg.
reproductive effect.
overall carcinogenic evaluation: Group 2B.
Animal toxicity[1]: human intramuscular LDLo: 418mg/Kg; human intravenous LDLo: 351mg/Kg.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent antineoplastic, antistatic abilities.
Ingredient description: the basic ingredients: bleomycin A2 and bleomycin B2.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
actives*, %, ≥
90
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 11056-06-7