Ibuprofen
time:2015-06-13 23:17:28,count:0

Ibuprofen
Alias
Hydratropic acid, p-isobutyl-
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-
Category
Anionic surfactants-Carboxylate
CAS No.
15687-27-1
Molecular Formula & Molecular Weight
Molecular Formula:C13H18O2
Molecular Weight:206.28
Structural Formula
Properties
Appearance: solid.
Solubility: slightly soluble in water.
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: guinea pig oral LD50: 495mg/Kg;
hamster oral LD50: 1690mg/Kg;
mouse intraperitoneal LD50: 320mg/Kg;
mouse oral LD50: 740mg/Kg;
mouse rectal LD50: 620mg/Kg;
mouse subcutaneous LD50: 395mg/Kg;
rabbit oral LD50: 1400mg/Kg;
rabbit rectal LD50: 830mg/Kg;
rat intraperitoneal LD50: 626mg/Kg;
rat oral LD50: 636mg/Kg;
rat rectal LD50: 530mg/Kg;
rat subcutaneous LD50: 740mg/Kg.
reproductive effect.
Human toxicity[1]: child oral LDLo: 469mg/Kg;
child oral TDLo: 480mg/Kg/17D-;
child oral TDLo: 500mg/Kg;
man oral LDLo: 171mg/Kg;
man oral TDLo: 120mg/Kg/W-I;
man oral TDLo: 180mg/Kg/3W-I;
man oral TDLo: 429mg/Kg;
man oral TDLo: 800mg/Kg;
man oral TDLo: 1028mg/Kg;
women oral TDLo: 8mg/Kg;
women oral TDLo: 132mg/Kg/6D-I.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent anti-inflammatory, emulsifying, dispersing abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
Actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Use as emulsifying agent, dispersing agent.
Conditioning agent in personal care products.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 15687-27-1

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