Metolazone
time:2015-07-16 15:59:51,count:0

Metolazone
Alias
6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-
Category
Non-ionic surfactants-Amide
CAS No.
17560-51-9
Molecular Formula & Molecular Weight
Molecular Formula: C16H16ClN3SO3
Molecular Weight: 365.83
Structural Formula
Properties
Appearance: solid.
Solubility: slightly soluble in water.
Stability: stable.
Risk: irritation, irritation to skin, eye.
Animal toxicity[1]: mouse intraperitoneal LD50: > 1500mg/Kg;
mouse oral LD50: > 5000mg/Kg;
mouse subcutaneous LD50: > 5000mg/Kg;
rat intraperitoneal LD50: > 5000mg/Kg;
rat oral LD50: > 5000mg/Kg;
rat subcutaneous LD50: > 5000mg/Kg.
reproductive effect.
Human toxicity[1]: man oral TDLo: 2mg/Kg/2W-I; women oral TDLo: 0.15mg/Kg.
Ecology: may be hazardous to environment. Water body should be given special attention.
Biodegradability: biodegradable.
Characteristics: excellent antihypertensive, diuretic, dispersing abilities.
Synthesis
 
Quality standards & test methods
item
physical and chemical indexes
test methods
Actives*, %, ≥
95
 
*: should be marked on molecular weight.
Major Uses
Use as pharmaceutical ingredient.
Manufacturers
 
References
[1]:http://toxnet.nlm.nih.gov/: 17560-51-9

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